abstract：:Aging is associated with a progressive decline of muscle mass, strength, and quality, a condition described as sarcopenia of aging. Despite the significance of skeletal muscle atrophy, the mechanisms responsible for the deterioration of muscle performance are only partially understood. The purpose of this review is to...

journal_title：Experimental gerontology

authors： Thompson LV

更新日期：2009-01-01 00:00:00

abstract：:Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in variou...

journal_title：Experimental gerontology

authors： Kukat A,Trifunovic A

更新日期：2009-01-01 00:00:00

abstract：:Mitochondrial proton leak may modulate reactive oxygen species (ROS) production and play a role in aging. The purpose of this study was to determine proton leak across the life span in skeletal mitochondria from calorie-restricted and UCP2/3 overexpressing mice. Proton leak in isolated mitochondria and markers of oxid...

journal_title：Experimental gerontology

authors： Asami DK,McDonald RB,Hagopian K,Horwitz BA,Warman D,Hsiao A,Warden C,Ramsey JJ

更新日期：2008-12-01 00:00:00

abstract：:Previous studies have indicated that genetic variations in the factors of insulin/insulin-like growth factor 1 (IGF-1) signaling pathway could influence human life-span by affecting IGF-1 levels. The promoter region of the IGF-1 gene is an obvious candidate and has not been studied clearly. To explore the potential ro...

journal_title：Experimental gerontology

authors： Xie L,Gong YY,Lian SG,Yang J,Yang Y,Gao SJ,Xu LY,Zhang YP

更新日期：2008-10-01 00:00:00

abstract：:The observation that long-lived and relatively healthy animals can be obtained by simple genetic manipulation prompts the search for chemical compounds that have similar effects. Since aging is the most important risk factor for many socially and economically important diseases, the discovery of a wide range of chemic...

journal_title：Experimental gerontology

authors： Benedetti MG,Foster AL,Vantipalli MC,White MP,Sampayo JN,Gill MS,Olsen A,Lithgow GJ

更新日期：2008-10-01 00:00:00

abstract：:We investigated the telomere lengths of individual cell types in lingual mucosa using an improved tissue quantitative fluorescence in situ hybridization (Q-FISH) method. Our tissue Q-FISH method compensates for partially cut nuclei in a tissue section by using the telomere:centromere ratio (TCR). We normalized our TCR...

journal_title：Experimental gerontology

authors： Aida J,Izumiyama-Shimomura N,Nakamura K,Ishikawa N,Poon SS,Kammori M,Sawabe M,Arai T,Matsuura M,Fujiwara M,Kishimoto H,Takubo K

更新日期：2008-09-01 00:00:00

abstract：:The hypotheses were: HISS-dependent insulin resistance (HDIR) accounts for insulin resistance that occurs with aging; HDIR is the initiating metabolic defect that leads progressively to type 2 diabetes and the metabolic syndrome; a synergistic antioxidant cocktail in chow confers protection against HDIR, subsequent sy...

journal_title：Experimental gerontology

authors： Lautt WW,Ming Z,Macedo MP,Legare DJ

更新日期：2008-08-01 00:00:00

abstract：:The echidna Tachyglossus aculeatus is a monotreme mammal from Australia that is exceptionally long-living. Its documented maximum lifespan of 50 years is 3.7 times that predicted from its body mass. Other exceptionally long-living mammals (naked mole-rats and humans) are known to have peroxidation-resistant membrane c...

journal_title：Experimental gerontology

authors： Hulbert AJ,Beard LA,Grigg GC

更新日期：2008-08-01 00:00:00

abstract：:Injured skeletal muscle generally regenerates less efficiently with age, but little is understood about the effects of ageing on the very early inflammatory and neovascular events in the muscle repair process. This study used a total of 174 whole muscle grafts transplanted within and between young and old mice to anal...

journal_title：Experimental gerontology

authors： Smythe GM,Shavlakadze T,Roberts P,Davies MJ,McGeachie JK,Grounds MD

更新日期：2008-06-01 00:00:00

abstract：:The essentiality of zinc for humans was recognized only 40 years ago. Zinc deficiency was suspected to occur in Iranian patients with growth retardation, hypogonadism in males, hepato-splenomegaly, rough and dry skin, geophagia and severe iron deficiency anemia. Later we documented zinc deficiency in similar patients ...

journal_title：Experimental gerontology

authors： Prasad AS

更新日期：2008-05-01 00:00:00

abstract：:Cellular senescence is regulated by specific genes in many organisms. The identification and functional analysis of senescence-associated genes could provide valuable insights into the senescence process. Here, we employed a new and improved differential display reverse transcription-polymerase chain reaction (DDRT-PC...

journal_title：Experimental gerontology

authors： Kim TW,Kim HJ,Lee C,Kim HY,Baek SH,Kim JH,Kwon KS,Kim JR

更新日期：2008-04-01 00:00:00

abstract：:Ageing is defined as the loss of ability to maintain cellular homeostasis of an organism associated with the free radical-elicited oxidative damage to cellular macromolecules. The aim of this study was to evaluate the efficacy of epigallocatechin-3-gallate (EGCG), the key component of green tea catechins on attenuatin...

journal_title：Experimental gerontology

authors： Senthil Kumaran V,Arulmathi K,Srividhya R,Kalaiselvi P

更新日期：2008-03-01 00:00:00

abstract：:Several studies have shown that centenarians have better cardiovascular risk profiles compared to younger old people. Some reports have revealed that cardiovascular diseases (i.e. hypertension, diabetes, angina and/or myocardial infarction) are less common in centenarians respect to 70 and 80 years old persons. In ord...

journal_title：Experimental gerontology

authors： Galioto A,Dominguez LJ,Pineo A,Ferlisi A,Putignano E,Belvedere M,Costanza G,Barbagallo M

更新日期：2008-02-01 00:00:00

abstract：:Skeletal remodelling is a continuous process during life and is still active also in extreme senescence. In the elderly, bone resorption often prevails over bone formation, causing bone loss and fragility. Elderly subjects are exposed to the risk of fractures, and loss of self-sufficiency, if considering that the prox...

journal_title：Experimental gerontology

authors： Passeri G,Vescovini R,Sansoni P,Galli C,Franceschi C,Passeri M,Italian Multicentric Study on Centenarians (IMUSCE).

更新日期：2008-02-01 00:00:00

abstract：:Reactive oxygen species (ROS) play important roles in cellular senescence and organismic aging. Furthermore, they have been implicated in some of the adverse effects of chronic stress due to elevated peripheral levels of catecholamines. Here, we applied three different techniques to individually compare the systemic a...

journal_title：Experimental gerontology

authors： Schraml E,Quan P,Stelzer I,Fuchs R,Skalicky M,Viidik A,Schauenstein K

更新日期：2007-11-01 00:00:00

abstract：:Telomeres serve as a mitotic clock and biological marker of senescence. Diabetes mellitus (DM) is associated with damage to target organs and premature aging. We assessed the effect of glycemic control on telomere dynamics in arterial cells of 58 patients undergoing coronary artery bypass and in mononuclear blood cell...

journal_title：Experimental gerontology

authors： Uziel O,Singer JA,Danicek V,Sahar G,Berkov E,Luchansky M,Fraser A,Ram R,Lahav M

更新日期：2007-10-01 00:00:00

abstract：:Neuroinflammation may play a role in the pathogenesis of Parkinson's disease (PD). The present study questioned whether this neuroinflammatory response differs between the olfactory bulb, as an early affected region and the nigrostriatal system. Indeed, increased microgliosis was shown in post-mortem olfactory bulb of...

journal_title：Experimental gerontology

authors： Vroon A,Drukarch B,Bol JG,Cras P,Brevé JJ,Allan SM,Relton JK,Hoogland PV,Van Dam AM

更新日期：2007-08-01 00:00:00

abstract：:Protein nitration occurs as a result of oxidative stress induced by reactive oxygen (ROS) and reactive nitrogen species (RNS). Therefore, protein nitration serves as a hallmark for protein oxidation in vivo. We have previously reported on age dependent protein nitration in cardiac tissue of Fisher 344 BN-F1 rats analy...

journal_title：Experimental gerontology

authors： Hong SJ,Gokulrangan G,Schöneich C

更新日期：2007-07-01 00:00:00

abstract：:Accumulation of CD28(-)CD8 T cells that are defective in response to antigenic stimulation is a hallmark of age-associated decline in T cell function. However, the underlying mechanism of this age-associated change is not fully understood. We recently analyzed the global gene expression profiles of CD8 T cell subsets ...

journal_title：Experimental gerontology

authors： Godlove J,Chiu WK,Weng NP

更新日期：2007-05-01 00:00:00

abstract：:The elderly exhibit reduced responses to vaccinations, leaving them more susceptible to preventable infectious diseases such as influenza and pneumonia. It has been unclear as to the specific changes in the aging immune system that contribute to this decline, thus we have developed a mouse model to examine this phenom...

journal_title：Experimental gerontology

authors： Haynes L

更新日期：2007-05-01 00:00:00

abstract：:The concept that lifespan is a function of the capacity to withstand extrinsic stress is very old. In concordance with this, long-lived individuals often have increased resistance against a variety of stresses throughout life. Genes underlying the stress response may therefore have the ability to affect lifespan. The ...

journal_title：Experimental gerontology

authors： Vermeulen CJ,Loeschcke V

更新日期：2007-03-01 00:00:00

abstract：:We previously demonstrated that in vitro stimulated splenic B cells from senescent mice are deficient in production of multiple class switch isotypes, class switch recombination (CSR), induction of the E2A-encoded transcription factor E47, and activation-induced cytidine deaminase (AID) which is necessary for CSR and ...

journal_title：Experimental gerontology

authors： Frasca D,Riley RL,Blomberg BB

更新日期：2007-03-01 00:00:00

abstract：:The results of life table experiments to determine the effects of artificial impairment (leg amputation) in 7500 Drosophila melanogaster adults revealed that the extent to which life expectancy was reduced in impaired individuals was conditional on: (1) leg location and number amputated--front leg had greatest impact ...

journal_title：Experimental gerontology

authors： Carey JR,Pinter-Wollman N,Wyman M,Müller HG,Molleman F,Zhang N

更新日期：2007-03-01 00:00:00

abstract：:Aging is known to be associated with a decrease of learning and memory. Little is known on the specificity of this process. In Drosophila, two forms of consolidated memory have been observed. Anesthesia-resistant memory (ARM) is formed after one or several consecutive training sessions whereas long-term memory (LTM) i...

journal_title：Experimental gerontology

authors： Mery F

更新日期：2007-01-01 00:00:00

abstract：:Aged traumatic brain injury (TBI) patients suffer higher rates of mortality and disability than younger patients. Cognitive problems common to TBI patients are associated with damage to the hippocampus, a central locus of learning and memory. To investigate the molecular mechanisms of age-related vulnerability to brai...

journal_title：Experimental gerontology

authors： Shah SA,Prough DS,Garcia JM,DeWitt DS,Hellmich HL

更新日期：2006-11-01 00:00:00

abstract：:Accumulation of oxidative stress-induced damage in brain tissue plays an important role in the pathogenesis of normal aging and neurodegenerative diseases. Neuronal oxidative damage typically increases with age in humans, and also in the invertebrate and vertebrate model species most commonly used in aging research. B...

journal_title：Experimental gerontology

authors： Seehuus SC,Krekling T,Amdam GV

更新日期：2006-11-01 00:00:00

abstract：:Calorie restriction (CR) may affect glucose tolerance via modulation of the insulin action in skeletal muscle. The present study investigated the effect of CR initiated at middle age in rats bearing glucose intolerance, in comparison with CR at a younger age. Male F344 rats at 2.5 and 18months (mo) of age were fed ad ...

journal_title：Experimental gerontology

authors： Park S,Komatsu T,Hayashi H,Yamaza H,Chiba T,Higami Y,Kuramoto K,Shimokawa I

更新日期：2006-09-01 00:00:00

abstract：:This study was aimed at determining the effect of exercise and vitamin E on age-associated changes in the superoxide dismutase (SOD), lipid (LPO) and protein oxidations (PO) in the cerebral cortex (CC), cerebellum (CB) and hippocampus (HC) of rat brain. For this, male Wistar albino rats of 4- (adult), 12- (middle-age)...

journal_title：Experimental gerontology

authors： Jolitha AB,Subramanyam MV,Asha Devi S

更新日期：2006-08-01 00:00:00

abstract：:Young rhesus monkey females (Macaca mulatta) demonstrate the well-defined circadian rhythm in activity of erythrocyte SOD with maximum at 10.00 h and minimum at 22.00 h. However, neither GSH-Px nor GR demonstrated any significant circadian changes, contrastingly to SOD. The diurnal changes in the SOD activity tightly ...

journal_title：Experimental gerontology

authors： Goncharova ND,Shmaliy AV,Bogatyrenko TN,Koltover VK

更新日期：2006-08-01 00:00:00

abstract：:Increasing evidence suggests an important role of mitochondrial dysfunction in the pathogenesis of many common age-related neurodegenerative diseases, including Alzheimer's disease (AD). AD is the most common neurodegenerative disorder characterized by dementia, memory loss, neuronal apoptosis and eventually death of ...

journal_title：Experimental gerontology

authors： Hauptmann S,Keil U,Scherping I,Bonert A,Eckert A,Müller WE

更新日期：2006-07-01 00:00:00

abstract：:Since,D-galactose (D-gal) overload model has been used as a premature aging model, we hypothesized that it may also lead to accelerated aging in the inner ear. Furthermore, though the mitochondrial DNA (mtDNA) 4834 bp deletion mutation has been considered as the marker of aging, there is no information available in th...

journal_title：Experimental gerontology

authors： Kong WJ,Wang Y,Wang Q,Hu YJ,Han YC,Liu J

更新日期：2006-06-01 00:00:00

abstract：:Accumulation of altered proteins is the most common molecular symptom of ageing. Altered proteins are also associated with many age-related pathologies. Altered proteins are continuously produced but are normally selectively degraded by cellular proteases; their accumulation during ageing may be explained by either or...

journal_title：Experimental gerontology

authors： Hipkiss AR

更新日期：2006-05-01 00:00:00

abstract：:Connexin 43 (Cx43) is the constitutive protein for the formation of cardiac gap junctions and therefore essential for cell-cell coupling and normal cardiac function. Apart from its localization at the sarcolemma, Cx43 is present in the inner mitochondrial membrane. Cx43 is involved in cardiomyocyte free oxygen radical...

journal_title：Experimental gerontology

authors： Boengler K,Heusch G,Schulz R

更新日期：2006-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the accumulation and aggregation of misfolded proteins. The presence of misfolded proteins in the endoplasmic reticulum (ER) triggers a cellular stress response called the unfolded protein response (UPR). Previously, we have shown that the UPR is activated in AD neurons. In...

journal_title：Experimental gerontology

authors： Hoozemans JJ,Stieler J,van Haastert ES,Veerhuis R,Rozemuller AJ,Baas F,Eikelenboom P,Arendt T,Scheper W

更新日期：2006-04-01 00:00:00

abstract：:In muscles, sarcopenia, the loss of muscle mass, is the major cause of aging-related functional decline and frailty. Several factors are correlated with sarcopenia during aging, including contraction-related cellular injury, oxidative stress, endocrine changes and reduced regenerative potential. However the involvemen...

journal_title：Experimental gerontology

authors： Chow DK,Glenn CF,Johnston JL,Goldberg IG,Wolkow CA

更新日期：2006-03-01 00:00:00

abstract：:Reproductive senescence occurs in all female mammals with resultant changes in numerous body functional systems and several important features may be species-specific. Those features that appear to parallel human menopause and aging include general similarity of hormone profiles across the menopausal transition, progr...

journal_title：Experimental gerontology

authors： Danilovich N,Ram Sairam M

更新日期：2006-02-01 00:00:00

abstract：:To counteract the debilitating progression of sarcopenia, a protein supplement should provide an energetically efficient anabolic stimulus. We quantified net muscle protein synthesis in healthy elderly individuals (65-79 yrs) following ingestion of an isocaloric intact whey protein supplement (WY; n=8) or an essential...

journal_title：Experimental gerontology

authors： Paddon-Jones D,Sheffield-Moore M,Katsanos CS,Zhang XJ,Wolfe RR

更新日期：2006-02-01 00:00:00

abstract：:Understanding telomere biology is of utmost importance for aging and cancer research. An essential tool is the determination of telomere length, which traditionally is done by telomere restriction fragment analysis, a laborious and time consuming method. Therefore, large efforts have been made to establish alternative...

journal_title：Experimental gerontology

authors： Wieser M,Stadler G,Böhm E,Borth N,Katinger H,Grillari J,Voglauer R

更新日期：2006-02-01 00:00:00

abstract：:Stem cells are located throughout the adult body of higher organisms, supporting a continuous renewal and repair of tissues. Unique abilities of stem cells are self-renewal and multipotential differentiation. It is, therefore, of critical importance for an organism to maintain and control quantity and quality of stem ...

journal_title：Experimental gerontology

authors： Fehrer C,Lepperdinger G

更新日期：2005-12-01 00:00:00

abstract：:In many eukaryotes oxidative phosphorylation via the mitochondrial electron transport chain provides the major means of ATP production. Complete removal of this capacity often results in premature death. Recent studies using the nematode Caenorhabditis elegans are surprising because they have revealed that disruption ...

journal_title：Experimental gerontology

authors： Rea SL

更新日期：2005-11-01 00:00:00